• PD-1/ PDL-1 role in cancer o MOA • DNA Mismatch repair-deficient in CRC – M

• PD-1/ PDL-1 role in cancer
o MOA
• DNA Mismatch repair-deficient in CRC
– MOA
• Anti-PD-1 MAB role in CRC
•
• dostarlimab (drug)
o MOA
o Applications
o Pre-clinical studies
o Clinical studies
Table of clnical trials list from clinicaltrials.gov
• other inhibitors for mismatch repair
conclusion and future direction