Neuroscientists have tried to aid in the development of promising interventions

Neuroscientists have tried to aid in the development of promising interventions and applications to help assist clinical patients with neurological disorders, however, much research has, thus far, failed to add valuable insight to the clinical field. The collaboration between neurologists in clinics, neuropathologists, neuroradiologists and neuroscientists in wet and dry labs is particularly important in magnifying clinical concerns, selecting appropriate methodological approaches, inventing tools and technologies, and translating these findings into interventions and treatments for patients. This Topic will, therefore, help to direct tomorrow’s translational neuroscience (bench to bedside) research into meaningful clinical outcomes in collaboration with clinicians and neuroscientists in the fields of neurology and neuropsychiatry. Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site in sufficient concentrations. Nanomedicines have great potential for therapy of brain disorders but are still uncommon in clinical use despite decades of research and development. Here, we provide an update on nano-carrier strategies for improving brain drug delivery for treatment of brain tumors, focusing on liposomes, extracellular vesicles and biomimetic strategies as the most clinically feasible strategies. Finally, we describe the obstacles in translation of these technologies including pre-clinical models, analytical methods and regulatory issues.